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KMID : 0043320140370030315
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Archives of Pharmacal Research
2014 Volume.37 No. 3 p.315 ~ p.323
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Four new compounds from the bulbs of Lycoris aurea with neuroprotective effects against CoCl2 and H2O2-induced SH-SY5Y cell injuries
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Jin An
Li Xue
Zhu Yun Yun
Yu Heng Yi
Pi Hui Fang
Zhang Peng
Ruan Han Li
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Abstract
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Three new alkaloids, 2α-hydroxy-6-O-n-butyloduline, O-n-butyllycorenine, (?)-N-(chloromethyl)lycoramine (1?3), and a new phenolic compound, ((7S)-7-(4-hydroxyphenyl)-7-hydroxypropyl)-2′-methylbenzene-3′,6′-diol (14), along with ten known alkaloids (4?13), were isolated from the bulbs of Lycoris aurea collected from Huaihua County of Hunan Province, China. Their structures were elucidated by spectroscopic methods including HRESIMS, UV, IR, and NMR. All the isolated compounds were tested for their neuroprotective effects against CoCl2 and H2O2-induced SH-SY5Y cell death. Compounds 1?7 and 10 exhibited significant neuroprotective effects against CoCl2-induced SH-SY5Y cell injury, while compounds 1?5, 7, 10 and 12 showed obvious neuroprotective effects against H2O2-induced SH-SY5Y cell death.
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KEYWORD
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Lycoris aurea, Amaryllidaceae alkaloids, Phenolic compound, Neuroprotective
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